Indium-Mediated Synthesis of Benzylic Hydroperoxides.

Author(s) Hou, Y.; Hu, J.; Xu, R.; Pan, S.; Zeng, X.; Zhong, G.
Journal Org Lett
Date Published 2019 Jun 21

An indium(0)-metal-mediated efficient synthesis of benzylic hydroperoxides is described. The reaction proceeds efficiently with a broad range of benzyl bromides under aerobic conditions at room temperature to afford benzyl hydroperoxides in good to excellent yields. In addition, the tandem hydroperoxidation-Michael addition of ( E)-1-(bromomethyl)-2-(2-nitrovinyl)benzene was also demonstrated.

DOI 10.1021/acs.orglett.9b01070
ISSN 1523-7052
Citation Org Lett. 2019;21(12):44284432.