Influence of doping ion, capping agent and pH on the fluorescence properties of zinc sulfide quantum dots: Sensing of Cu and Hg ions and their biocompatibility with cancer and fungal cells.

Author(s) Desai, M.L.; Deshmukh, B.; Lenka, N.; Haran, V.; Jha, S.; Basu, H.; Singhal, R.Kumar; Sharma, P.K.; Kailasa, S.Kumar; Kim, K.H.
Journal Spectrochim Acta A Mol Biomol Spectrosc
Date Published 2019 Mar 05
Abstract

Herein, a facile one-pot synthetic method was explored for the fabrication of glutathione capped Mn doped‑zinc sulphide quantum dots (GSH-Mn-ZnS QDs) for both fluorescent detection of Cu and Hg ions and for fluorescence imaging of two cancer (RIN5F and MDAMB231) and fungal (Rhizopus oryzae) cells. Particularly, doping of Mn into ZnS QDs nanocrystal structure resulted a great improvement in the fluorescence properties of ZnS QDs. The emission peak of undoped ZnS QDs was found at 447 nm, which is due to the large number of surface defects in the ZnS QDs nanostructures. Under identical conditions, there is a good linear relationship between the quenching of fluorescence intensity and analytes (Cu and Hg ions) concentration in the range of 0.005 to 0.2 mM and of 0.025 to 0.4 mM for Cu and Hg ions, respectively. The GSH-Mn-ZnS QDs exhibit least cytotoxicity against RIN5F and MDAMB231 cells, demonstrating the multifunctional applications in sensing of metal ions and biocompatibility towards cancer (RIN5F and MDAMB231) and fungal (Rhizopus oryzae) cells.

DOI 10.1016/j.saa.2018.11.027
ISSN 1873-3557
Citation Desai ML, Deshmukh B, Lenka N, Haran V, Jha S, Basu H, et al. Influence of doping ion, capping agent and pH on the fluorescence properties of zinc sulfide quantum dots: Sensing of Cu and Hg ions and their biocompatibility with cancer and fungal cells. Spectrochim Acta A Mol Biomol Spectrosc. 2019;210:212-221.

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