Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements.

Author(s) Gu, Z.; Wang, S.; Weng, W.; Chen, X.; Cao, L.; Wei, J.; Shin, J.W.; Su, J.
Journal Mater Sci Eng C Mater Biol Appl
Date Published 2017 Jun 01
Abstract

In this study, composite cements containing mesoporous magnesium silicate (m-MS) and calcium sulfate (CS) were fabricated. The results revealed that the setting time of the m-MS/CS composite cements (m-MSC) slightly prolonged with the increase of m-MS content while the compressive strength suffered a little loss. The doping of m-MS improved the water absorption, drug release (vancomycin) and degradability of the m-MSC in Tris-HCl solution (pH=7.4). In addition, addition of m-MS facilitated the apatite-mineralization of m-MSC in simulated body fluid (SBF), indicating good bioactivity. For cell cultural experiments, the results revealed that the m-MSC promoted the cells adhesion and proliferation, and improved the alkaline phosphatase (ALP) activity of MC3T3-E1 cells, revealing good cytocompatibility. It could be suggested that the m-MSC might be promising cements biomaterials for bone tissue regeneration.

DOI 10.1016/j.msec.2017.02.100
ISSN 1873-0191
Citation Gu Z, Wang S, Weng W, Chen X, Cao L, Wei J, et al. Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements. Mater Sci Eng C Mater Biol Appl. 2017;75:620-628.

Related Applications, Forms & Industries