Intermolecular scandium triflate-promoted nitrene-transfer [5 + 1] cycloadditions of vinylcyclopropanes.

Author(s) Laudenschlager, J.E.; Combee, L.A.; Hilinski, M.K.
Journal Org Biomol Chem
Date Published 2019 Oct 23

Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. This represents the second example of a [5 + 1] nitrene-transfer cycloaddition and exhibits complementary substrate scope to the antecedent work, expanding the range of N-heterocycles accessible via this strategy.

DOI 10.1039/c9ob01858a
ISSN 1477-0539
Citation Org Biomol Chem. 2019.

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