Iodine-Catalyzed Direct C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes.
Title | Iodine-Catalyzed Direct C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes. |
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Authors | Zhang, Z.; Pi, C.; Tong, H.; Cui, X.; Wu, Y. |
Journal | Org Lett |
DOI | 10.1021/acs.orglett.6b03399 |
Abstract |
An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes catalyzed by iodine under metal- and external oxidant-free reaction conditions has been developed. A variety of (E)-2-styrylazaheterocycles have been produced in moderate to excellent yields. The mechanistic exploration indicated that the N-oxide group played dual roles as both the directing group and an internal oxidant in this catalytic cycle. |