Iridium-Catalyzed Asymmetric Hydrogenation of Benzo[b]thiophene 1,1-Dioxides.

Author(s) Tosatti, P.; Pfaltz, A.
Journal Angew Chem Int Ed Engl
Date Published 2017 Apr 10

An efficient iridium-catalyzed asymmetric hydrogenation of substituted benzothiophene 1,1-dioxides is described. The use of iridium complexes with chiral pyridyl phosphinite ligands provides access to highly enantiomerically enriched sulfones with substituents at the 2- and 3-position. Sulfones of this type are of interest as core structures of agrochemicals and pharmaceuticals. Moreover, they can be further reduced to chiral 2,3-dihydrobenzothiophenes.

DOI 10.1002/anie.201701409
ISSN 1521-3773
Citation Angew Chem Int Ed Engl. 2017;56(16):45794582.

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