Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source.

Title Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source.
Authors Tsukamoto, Y.; Itoh, S.; Kobayashi, M.; Obora, Y.
Journal Org Lett
DOI 10.1021/acs.orglett.9b01025
Abstract

IrCl(cod)]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. The reaction processed high atom economy and efficient. By applying the reaction system, the synthesis method of naproxen was provided.

Citation Tsukamoto, Y.; Itoh, S.; Kobayashi, M.; Obora, Y..Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source..

Related Elements

Iridium

See more Iridium products. Iridium (atomic symbol: Ir, atomic number: 77) is a Block D, Group 9, Period 6 element with an atomic weight of 192.217. The number of electrons in each of iridium's shells is [2, 8, 18, 32, 15, 2] and its electron configuration is [Xe] 4f14 5d7 6s2. Iridium Bohr ModelThe iridium atom has a radius of 136 pm and a Van der Waals radius of 202 pm. Iridium was discovered and first isolated by Smithson Tennant in 1803. In its elemental form, Iridium has a silvery white appearance. Iridium is a member of the platinum group of metals.Elemental Iridium It is the most corrosion resistant metal known and is the second-densest element (after osmium). It will not react with any acid and can only be attacked by certain molten salts, such as molten sodium chloride. Iridium is found as an uncombined element and in iridium-osmium alloys. Iridium's name is derived from the Greek goddess Iris, personification of the rainbow, on account of the striking and diverse colors of its salts.