Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source.

Author(s) Tsukamoto, Y.; Itoh, S.; Kobayashi, M.; Obora, Y.
Journal Org Lett
Date Published 2019 Apr 17
Abstract

IrCl(cod)]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. The reaction processed high atom economy and efficient. By applying the reaction system, the synthesis method of naproxen was provided.

DOI 10.1021/acs.orglett.9b01025
ISSN 1523-7052
Citation Tsukamoto Y, Itoh S, Kobayashi M, Obora Y. Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source. Org Lett. 2019.

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