Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides.

Author(s) Zhao, H.; Gao, Q.; Zhang, Y.; Zhang, P.; Xu, S.
Journal Org Lett
Date Published 2020 Apr 03

Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.

DOI 10.1021/acs.orglett.0c00977
ISSN 1523-7052
Citation Org Lett. 2020;22(7):28612866.