Iron doped β-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation.

Author(s) Singh, R.Kishore; Srivastava, M.; Prasad, N.K.; Awasthi, S.; Dhayalan, A.; Kannan, S.
Journal Mater Sci Eng C Mater Biol Appl
Date Published 2017 Sep 01
Abstract

The ability of β-Tricalcium phosphate [β-TCP, β-Ca3(PO4)2] to host iron at its structural lattice and its associated magnetic susceptibility, hyperthermia effect, biocompatibility and mechanical characteristics is investigated. The studies revealed the ability of β-Ca3(PO4)2 to host 5.02mol% of Fe(3+) at its Ca(2+)(5) site. Excess Fe(3+) additions led to the formation of trigonal Ca9Fe(PO4)7 and moreover a minor amount of CaFe3(PO4)3O crystallization was also observed. A gradual increment in the iron content at β-Ca3(PO4)2 results in the simultaneous effect of pronounced hyperthermia effect and mechanical stability. However, the presence of CaFe3(PO4)3O contributes for the reduced hyperthermia effect and mechanical stability of iron substituted β-Ca3(PO4)2. Haemolytic tests, cytotoxicity tests and ALP gene expression analysis confirmed the biocompatibility of the investigated systems.

DOI 10.1016/j.msec.2017.04.130
ISSN 1873-0191
Citation Singh RK, Srivastava M, Prasad NK, Awasthi S, Dhayalan A, Kannan S. Iron doped β-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation. Mater Sci Eng C Mater Biol Appl. 2017;78:715-726.

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