Author(s) Hong, X.; Tan, Q.; Liu, B.; Xu, B.
Journal Angew Chem Int Ed Engl
Date Published 2017 Mar 27

A novel and direct approach to alkyl/aryl heteroarene sulfonic esters using copper sulfate as the environmentally benign inorganic sulfonation reagent was first realized with the aid of isocyanide. A variety of heterocycles reacted to afford the corresponding sulfonic esters through C-H functionalization. In this transformation, the otherwise inert copper sulfate was unusually activated by an isocyanide and employed as the source of the sulfonic substituents in an unprecedented fashion. The findings suggest that an appropriate activator may liberate the chemical activities of some relatively inert inorganic salts for organic synthesis.

DOI 10.1002/anie.201612565
ISSN 1521-3773
Citation Angew Chem Int Ed Engl. 2017;56(14):39613965.

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