Light-activated Rhenium Complexes with Dual Mode of Action against Bacteria.

Author(s) Frei, A.; Amado, M.; Cooper, M.A.; Blaskovich, M.A.T.
Journal Chemistry
Date Published 2019 Dec 01
Abstract

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

DOI 10.1002/chem.201904689
ISSN 1521-3765
Citation Chemistry. 2019.

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