Lysine-Functionalized Tungsten Disulfide Quantum Dots as Artificial Enzyme Mimics for Oxidative Stress Biomarker Sensing.

Author(s) Garg, M.; Vishwakarma, N.; Sharma, A.L.; Mizaikoff, B.; Singh, S.
Journal ACS Omega
Date Published 2020 Feb 04

The color generating from the biochemical reaction between 3,3',5,5'-tetramethylbenzidine and Lysine@WS QDs was used a signal for the detection of hydrogen peroxide. The QDs were prepared using a combination of techniques, that is, probe sonication and hydrothermal treatment. Analysis via UV-vis spectroscopy, Fourier transform infrared and Raman spectroscopy, X-ray diffraction, energy-dispersive spectroscopy, and transmission electron microscopy yielded detailed information on the nature and characteristics of these quantum dots. Furthermore, as-synthesized quantum dots were studied for their capability to mimic peroxidase enzyme using 3,3',5,5'-tetramethylbenzidine as a substrate. Consequently, a colorimetric sensor utilizing Lysine@WS QDs could detect hydrogen peroxide in a range of 0.1-60 μM with a response time of 5 min. The same material was used for HO detection using impedance spectroscopy, which yielded a dynamic range of 0.1-350 μM with a response time of 30-40 s.

DOI 10.1021/acsomega.9b03655
ISSN 2470-1343
Citation ACS Omega. 2020;5(4):19271937.

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