Manganese and Developmental Neurotoxicity.

Author(s) Lucchini, R.; Placidi, D.; Cagna, G.; Fedrighi, C.; Oppini, M.; Peli, M.; Zoni, S.
Journal Adv Neurobiol
Date Published 2017

Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex.Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.

DOI 10.1007/978-3-319-60189-2_2
Keywords Academic Performance; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Cognition; Cognitive Dysfunction; Drinking Water; Environmental Exposure; Executive Function; Heavy Metal Poisoning, Nervous System; Humans; Manganese Poisoning; Memory Disorders; Olfaction Disorders; Parkinsonian Disorders; Particulate Matter; Soil
ISSN 2190-5215
Citation Adv Neurobiol. 2017;18:1334.