Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides.

Author(s) Wu, J.; Kong, Y.; Liu, L.; Chang, W.; Li, J.
Journal Org Biomol Chem
Date Published 2018 Aug 22

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides. This four-component cascade reaction had advantages of mild reaction conditions, wide substrate scope and good atom economy. Four new bonds were formed in one pot via a 6-exo-dig iodothiolation cyclization of homopropargylic amines. The corresponding E-configurational thiazine imide products possess an exocyclic vinyliodide functional group.

DOI 10.1039/c8ob01557k
ISSN 1477-0539
Citation Org Biomol Chem. 2018;16(33):59555959.

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