Title | Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility. |
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Authors | J. Sun; X. Zheng; H. Li; D. Fan; Z. Song; H. Ma; X. Hua; J. Hui |
Journal | Mater Sci Eng C Mater Biol Appl |
DOI | 10.1016/j.msec.2016.12.106 |
Abstract |
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO3(2-) (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO3(2-) doping level of the Se/(P+Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P+Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone. |
Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility.