Multifunctional Magnetic Copper Ferrite Nanoparticles as Fenton-like Reaction and Near-Infrared Photothermal Agents for Synergetic Antibacterial Therapy.

Author(s) Liu, Y.; Guo, Z.; Li, F.; Xiao, Y.; Zhang, Y.; Bu, T.; Jia, P.; Zhe, T.; Wang, L.
Journal ACS Appl Mater Interfaces
Date Published 2019 Aug 13
Abstract

Synergistic therapeutic strategies for bacterial infection have attracted extensive attention owing to their enhanced therapeutic effects and less adverse effects compared with monotherapy. Herein we report a novel synergistic antibacterial platform that integrates the nanocatalytic antibacterial therapy and photothermal therapy (PTT) by hemoglobin functionalized copper ferrite nanoparticles (Hb-CFNPs). In the presence of a low concentration of hydrogen peroxide (H2O2), the excellent Fenton and Fenton-like reaction activity of Hb-CFNPs can effectively catalyze the decomposition of H2O2 to produce hydroxyl radicals (•OH), rendering an increase in the permeability of the bacterial cell membrane and the sensitivity to heat. With the assistance of NIR irradiation, the hyperthermia induced by Hb-CFNPs can cause the death of the damaged bacteria. Additionally, owing to the outstanding magnetic property of Hb-CFNPs, it can improve the photothermal efficiency by about 20 times via magnetic enrichment, which facilitates to realize excellent bactericidal efficacy at a very low experimental dose (20 μg/mL). In vitro antibacterial experiment shows that this synergistic antibacterial strategy has a broad-spectrum antibacterial property against Gram-negative Escherichia coli (E.coli, 100%) and Gram-positive Staphylococcus aureus (S.aureus, 96.4%). More importantly, in vivo S.aureus-infected abscess treatment studies indicate that Hb-CFNPs can serve as an antibacterial candidate with negligible toxicity to realize synergistic treatment of bacterial infections through catalytic and photothermal effects. Accordingly, this study proposes a novel, high-efficiency and multifunctional therapeutic system for the treatment of bacterial infection, which will open up a new avenue for the design of synergistic antibacterial systems in the future.

DOI 10.1021/acsami.9b10096
ISSN 1944-8252
Citation Liu Y, Guo Z, Li F, Xiao Y, Zhang Y, Bu T, et al. Multifunctional Magnetic Copper Ferrite Nanoparticles as Fenton-like Reaction and Near-Infrared Photothermal Agents for Synergetic Antibacterial Therapy. ACS Appl Mater Interfaces. 2019.

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