Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.

Author(s) Xu, Z.; Zhang, Y.; Zhang, S.; Jia, X.; Zhong, G.; Yang, Y.; Du, Q.; Li, J.J.; Liu, Z.
Journal Cancer Lett
Date Published 2019 Apr 10
Abstract

Herein we present half-sandwich Ir complexes [(η-Cp)Ir(OˆC)Cl] containing OˆC(NHC)-chelating ligand as anticancer and antimetastasis agents. All the complexes displayed high potency in vitro against a wide range of cancer cells. In addition, Ir2 significantly curb tumor growth in a colon cancer mouse xenograft model in vivo. Further mechanism of action studies indicate that Ir2-initiated apoptosis occurs through ROS-mediated cross-talk between mitochondria and lysosomes.

DOI 10.1016/j.canlet.2019.01.018
ISSN 1872-7980
Citation Xu Z, Zhang Y, Zhang S, Jia X, Zhong G, Yang Y, et al. Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes. Cancer Lett. 2019;447:75-85.

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