Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite.

Author(s) Pang, J.Hao; Kaga, A.; Chiba, S.
Journal Chem Commun (Camb)
Date Published 2018 Sep 11
Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

DOI 10.1039/c8cc05979a
ISSN 1364-548X
Citation Pang JH, Kaga A, Chiba S. Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite. Chem Commun (Camb). 2018;54(73):10324-10327.

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