Palladium catalyzed template directed C-5 selective olefination of thiazoles.

Author(s) Achar, T.Kumar; Biswas, J.Prasad; Porey, S.; Pal, T.; Ramakrishna, K.; Maiti, S.; Maiti, D.
Journal J Org Chem
Date Published 2019 May 23
Abstract

An efficient method has been developed to afford highly C-5 selective olefination of thiazole derivatives utilizing bifunctional template in an intermolecular fashion. Coordinative interaction between substrates and metal chelated template backbone plays crucial role for high selectivity. Excellent selectivity for C-5 position was observed while mono substituted (2- or 4-) or even more challenging unsubstituted thiazole were employed.

DOI 10.1021/acs.joc.9b01074
ISSN 1520-6904
Citation Achar TK, Biswas JP, Porey S, Pal T, Ramakrishna K, Maiti S, et al. Palladium catalyzed template directed C-5 selective olefination of thiazoles. J Org Chem. 2019.