Polyhydrazide-based organic nanotubes as extremely efficient and highly selective artificial iodide channels.

Author(s) Zeng, H.; Roy, A.; Joshi, H.; Ye, R.; Shen, J.; Chen, F.; Aksimentiev, A.
Journal Angew Chem Int Ed Engl
Date Published 2020 Jan 16

We report herein a series of pore-containing polymeric nanotubes based on an H-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of ~ 6.5 Å in diameter, are interestingly found to mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membrane. Polymer channel 1a , having an averaged molecular weight of 18.2 KDa and 3.6 nm in helical height, exhibits the highest anion transport activities with iodide ( EC 50 = 0.042 uM or 0.028 mol% relative to lipid) being transported 10 times more efficiently than chlorides ( EC 50 = 0.47 uM). Notably, even in cholesterol-rich environment, iodide transport activity still remains high with EC 50 of 0.37 uM. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.

DOI 10.1002/anie.201916287
ISSN 1521-3773
Citation Angew Chem Int Ed Engl. 2020.

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