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Praseodymium(III)-Catalyzed Regioselective Synthesis of C-N-Substituted Coumarins with Coumarins and Azides.
Title Praseodymium(III)-Catalyzed Regioselective Synthesis of C-N-Substituted Coumarins with Coumarins and Azides.
Authors Li, J.L.; Hu, D.C.; Liang, X.P.; Wang, Y.C.; Wang, H.S.; Pan, Y.M.
Journal J Org Chem
DOI 10.1021/acs.joc.7b01410
Abstract

A series of C-N-substituted coumarins were synthesized in good yields directly from coumarins and azides in the presence of Pr(OTf) without any additives or ligands needed. The selected compounds 3a, 3c-e, 3g, 3i, 3q, 3u, and 3v exhibited good anticancer activities against MGC-803, A549, and NCI-H460 cell lines with IC in the range 8.75-38.54 μmol L.