PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity.

Author(s) Popov, A.L.; Han, B.; Ermakov, A.M.; Savintseva, I.V.; Ermakova, O.N.; Popova, N.R.; Shcherbakov, A.B.; Shekunova, T.O.; Ivanova, O.S.; Kozlov, D.A.; Baranchikov, A.E.; Ivanov, V.K.
Journal Mater Sci Eng C Mater Biol Appl
Date Published 2020 Mar

Photochromic tungsten oxide (WO) nanoparticles stabilized by polyvinylpyrrolidone (PVP) were synthesized to evaluate their potential for biomedical applications. PVP-stabilized tungsten oxide nanoparticles demonstrated a highly selective cytotoxic effect on normal and cancer cells in vitro. WO nanoparticles were found to induce substantial cell death in osteosarcoma cells (MNNG/HOS cell line) with a half-maximal inhibitory concentration (IC50) of 5 mg/mL, while producing no, or only minor, toxicity in healthy human mesenchymal stem cells (hMSc). WO nanoparticles induced intracellular oxidative stress, which led to apoptosis type cell death. The selective anti-cancer effects of WO nanoparticles are due to the pH sensitivity of tungsten oxide and its capability of reactive oxygen species (ROS) generation, which is expressed in the modulation of genes involved in reactive oxygen species metabolism, mitochondrial dysfunction, and apoptosis.

DOI 10.1016/j.msec.2019.110494
ISSN 1873-0191
Citation Mater Sci Eng C Mater Biol Appl. 2020;108:110494.

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