Rhenium-Catalyzed Reduction of Carboxylic Acids with Hydrosilanes.

Author(s) Wei, D.; Buhaibeh, R.; Canac, Y.; Sortais, J.B.
Journal Org Lett
Date Published 2019 Oct 04
Abstract

Re(CO) efficiently catalyzes the direct reduction of various carboxylic acids under mild conditions (rt, irradiation 350 or 395 nm). While aliphatic carboxylic acids were readily converted to the corresponding disilylacetals with low catalyst loading (0.5 mol %) in the presence of EtSiH (2.2 equiv), aromatic analogues required more drastic conditions (Re(CO) 5 mol %, PhMeSiH 4.0 equiv) to afford the corresponding aldehydes after acid treatment.

DOI 10.1021/acs.orglett.9b02449
ISSN 1523-7052
Citation Wei D, Buhaibeh R, Canac Y, Sortais J-. Rhenium-Catalyzed Reduction of Carboxylic Acids with Hydrosilanes. Org Lett. 2019;21(19):7713-7716.