Rhodium-Catalyzed β-Selective Oxidative Heck-Type Coupling of Vinyl Acetate via C-H Activation.

Author(s) Zhang, H.J.; Lin, W.; Su, F.; Bin Wen, T.
Journal Org Lett
Date Published 2016 Dec 16
Abstract

An efficient Rh(III)-catalyzed direct ortho-C-H olefination of acetanilides with vinyl acetate was developed. This protocol provides a straightforward pathway to a series of (E)-2-acetamidostyryl acetates, giving access to indole derivatives following a simple hydrolysis/cyclization process.

DOI 10.1021/acs.orglett.6b03244
ISSN 1523-7052
Citation Zhang H-, Lin W, Su F, Bin Wen T-. Rhodium-Catalyzed β-Selective Oxidative Heck-Type Coupling of Vinyl Acetate via C-H Activation. Org Lett. 2016;18(24):6356-6359.

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