Rhodium-catalyzed asymmetric addition of arylboronic acids to 2H-chromenes leading to 3-arylchromane derivatives.

Author(s) Umeda, M.; Sakamoto, K.; Nagai, T.; Nagamoto, M.; Ebe, Y.; Nishimura, T.
Journal Chem Commun (Camb)
Date Published 2019 Oct 01
Abstract

Asymmetric addition of arylboronic acids to 2H-chromenes proceeded in the presence of a hydroxorhodium/chiral diene catalyst to give 3-arylchromanes in high yields with high enantioselectivity. The reaction involves 1,4-Rh shift before protonation to release the addition product and to regenerate the hydroxorhodium species.

DOI 10.1039/c9cc06221a
ISSN 1364-548X
Citation Umeda M, Sakamoto K, Nagai T, Nagamoto M, Ebe Y, Nishimura T. Rhodium-catalyzed asymmetric addition of arylboronic acids to 2H-chromenes leading to 3-arylchromane derivatives. Chem Commun (Camb). 2019;55(79):11876-11879.