Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles.

Author(s) Wang, N.; Liu, L.; Xu, W.; Zhang, M.; Huang, Z.; Shi, D.; Zhao, Y.
Journal Org Lett
Date Published 2019 Jan 08
Abstract

A rhodium(III)-catalyzed intermolecular C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. Moreover, the nitro-substituted ketoximes are well compatible in this reaction, leading to the corresponding products in moderate to good yields.

DOI 10.1021/acs.orglett.8b03488
ISSN 1523-7052
Citation Wang N, Liu L, Xu W, Zhang M, Huang Z, Shi D, et al. Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles. Org Lett. 2019.