Ruthenium-catalyzed -selective C-H bond formylation of arenes.

Author(s) Jia, C.; Wu, N.; Cai, X.; Li, G.; Zhong, L.; Zou, L.; Cui, X.
Journal J Org Chem
Date Published 2020 Mar 05

The -C-H bond formylation of arenes has been achieved using CHBr as a formyl source in the presence of [Ru(-cym)(OAc)] as catalyst. This method provides efficient access to the preparation of various -substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanism studies show that the key active species is a pentagonal ruthenacycle complex.

DOI 10.1021/acs.joc.0c00007
ISSN 1520-6904
Citation J Org Chem. 2020.

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