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Ruthenium(II)-Catalyzed meta C-H Mono- and Difluoromethylations by Phosphine/Carboxylate Cooperation.
Title Ruthenium(II)-Catalyzed meta C-H Mono- and Difluoromethylations by Phosphine/Carboxylate Cooperation.
Authors Ruan, Z.; Zhang, S.K.; Zhu, C.; Ruth, P.Niklas; Stalke, D.; Ackermann, L.
Journal Angew Chem Int Ed Engl
DOI 10.1002/anie.201611595
Abstract

Ruthenium(II)-catalyzed meta-selective C-H (di)fluoromethylation was accomplished by phosphine and carboxylate cooperation. The remote C-H functionalization was characterized by ample substrate scope, thereby setting the stage for meta-(di)fluoromethylation through facile C-H cleavage.