Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy.

Author(s) Guo, M.; Xiang, H.J.; Wang, Y.; Zhang, Q.L.; An, L.; Yang, S.P.; Ma, Y.; Wang, Y.; Liu, J.G.
Journal Chem Commun (Camb)
Date Published 2017 Mar 18
Abstract

A mitochondria-targeting nanoplatform for near-infrared-light-controlled release of nitric oxide accompanied by photothermal therapy was developed, which consists of ruthenium nitrosyl functionalized N-doped graphene quantum dots and a triphenylphosphonium moiety. The nanoplatform demonstrated both in vitro and in vivo anti-tumor efficacy upon irradiation with 808 nm light.

DOI 10.1039/c7cc00670e
ISSN 1364-548X
Citation Chem Commun (Camb). 2017;53(22):32533256.

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