Structure and dysprosium dopant engineering of gadolinium oxide nanoparticles for enhanced dual-modal magnetic resonance and fluorescence imaging.

Author(s) Yin, J.; Li, C.; Chen, D.; Yang, J.; Liu, H.; Hu, W.; Shao, Y.
Journal Phys Chem Chem Phys
Date Published 2017 Feb 15

We report a class of multi-functional core-shell nanoarchitectures, consisting of silica nanospheres as the core and Gd2O3:Dy(3+) nanocrystals as the ultra-thin shell, that enable unique multi-color living cell imaging and remarkable in vivo magnetic resonance imaging. These types of targeted cell imaging nanoarchitectures can be used as a variety of fluorescence nanoprobes due to the multi-color emissions of the Gd2O3:Dy(3+) nanophosphor. We also proposed a strategy of modulating core-shell structure design to achieve an enhanced magnetic resonance contrast ability of Gd2O3 nanoagents, and the classical Solomon-Bloembergen-Morgan theory was applied to explicate the mechanism underlying the enhancement. The as-synthesized ligand-free nanomaterial possesses a suitable particle size for cellular uptake as well as avoiding penetrating the blood-brain barrier with good water-solubility, stability, dispersibility and uniformity. The extremely low cytotoxicity and favorable biocompatibility obtained from in vitro and in vivo bioassays of the as-designed nanoparticles indicate their excellent potential as a candidate for functioning as a targeted nanoprobe.

DOI 10.1039/c6cp06712c
ISSN 1463-9084
Citation Phys Chem Chem Phys. 2017;19(7):53665376.

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