Synthesis, DNA binding and antimicrobial studies on rhodium(II) complexes of dicyandiamide.

Author(s) Devi, P.; Singh, R.K.Hemakuma; Sujata, W.; Joshi, D.D.
Journal Nucleosides Nucleotides Nucleic Acids
Date Published 2020 Mar 04

The synthesis and characterization on four rhodium(II) complexes with the formula [Rh(CHCOO)(AMUH)(dcda)](CHCOO)(),[Rh(CHCOO)(AEUH)(dcda)](CHCOO)(),[Rh(CHCOO)(APrUH)(dcda)](CHCOO)(),[Rh(CHCOO)(ABUH)(dcda)](CHCOO)(), where AMUH = 1-amidino-O-methylurea, AEUH = 1-amidino-O-ethylurea, APrUH = 1-amidino-O-n-propylurea, ABUH = 1-amidino-O-n-butylurea, dcda = dicyandiamide are reported. The complexes were prepared by the reaction of dicyandiamide with rhodium(II) acetate in methanol (), ethanol (), n-propanol () and n-butanol () respectively and characterized by various techniques such as C, H, N analysis, FTIR, UV-Visible, EPR, conductance, SEM, EDX, powder XRD pattern and mass spectral studies. The interaction studies of the complexes with CT-DNA suggested the non-intercalative mode of binding for these complexes. The antimicrobial activity of the complexes against the tested microorganisms viz and , using the standard antibiotics streptomycin as positive control is also reported.

DOI 10.1080/15257770.2020.1722164
ISSN 1532-2335
Citation Nucleosides Nucleotides Nucleic Acids. 2020:120.

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