Tellurate enters Escherichia coli K-12 cells via the SulT-type sulfate transporter CysPUWA.

Author(s) Goff, J.; Yee, N.
Journal FEMS Microbiol Lett
Date Published 2017 Dec 29
Abstract

Soluble forms of tellurium are environmental contaminants that are toxic to microorganisms. While tellurite [Te(IV)] is a well-characterized antimicrobial agent, little is known about the interactions of tellurate [Te(VI)] with bacterial cells. In this study, we investigated the role of sulfate transporters in the uptake of tellurate in Escherichia coli K-12. Mutant strains carrying a deletion of the cysW gene in the CysPUWA sulfate transporter system accumulated less cellular tellurium and exhibited higher resistance to tellurate compared with the wild-type strain. Complementation of the mutation restored tellurate sensitivity and uptake. These results indicate that tellurate enters E. coli cells to cause toxic effects via the CysPUWA sulfate transporter.

DOI 10.1093/femsle/fnx241
Keywords Anti-Bacterial Agents; Biological Transport; Drug Resistance, Bacterial; Escherichia coli K12; Escherichia coli Proteins; Genetic Complementation Test; Mutation; Protein Subunits; Tellurium
ISSN 1574-6968
Citation Goff J, Yee N. Tellurate enters Escherichia coli K-12 cells via the SulT-type sulfate transporter CysPUWA. FEMS Microbiol Lett. 2017;364(24).

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