Transferrin-Conjugated Superparamagnetic Iron Oxide Nanoparticles as In Vivo Magnetic Resonance Imaging Contrast Agents.

Author(s) Wang, J.; Zhang, B.; Yang, G.; Su, L.; Wang, L.; Gao, F.
Journal J Nanosci Nanotechnol
Date Published 2020 Apr 01

Poly(ethylene glycol) (PEG)/poly(ethylene imine) (PEI) modified superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition of iron (III) acetylacetonate (Fe(acac)₃) in PEG containing PEI. Transferrin (Tf) was employed to functionalize SPIONs. The potential of Tf-SPIONs as brain magnetic resonance (MR) imaging contrast agents was explored by using Kunming mice as an animal model. The experiments revealed that Tf-SPIONs exhibited an enhanced contrast time as compared with the PEG-SPIONs and PEG/PEI-SPIONs. Tf-SPIONs exhibit promising potential for bioimaging applications because of their advantages of dispersibility in water, low cytotoxicity and long circulation time in blood.

DOI 10.1166/jnn.2020.17311
ISSN 1533-4899
Citation J Nanosci Nanotechnol. 2020;20(4):20182024.

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