Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles.

Author(s) Vargová, D.; Pérez, J.M.; Harutyunyan, S.R.; Šebesta, R.
Journal Chem Commun (Camb)
Date Published 2019 Sep 26
Abstract

Here we show trapping of chiral enolates with carbenium ions, Michael acceptors, and bromine. Silyl ketene aminals, disilyl acetals, and aza-enolates were obtained via Lewis acid mediated enantioselective conjugate addition of Grignard reagents to unsaturated amides, carboxylic acids and alkenyl heterocycles.

DOI 10.1039/c9cc05041h
ISSN 1364-548X
Citation Chem Commun (Camb). 2019;55(78):1176611769.

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