Author(s) Andersen, K.E.; Vestergaard, M.E.; Christensen, L.P.
Journal Contact Dermatitis
Date Published 2014 Feb
Abstract

BACKGROUND: Allergic reactions to spectacle frames are not unusual. A patient had a reproducible strong allergic patch test reaction to scrapings from the plastic material, and negative patch test results with available spectacle frame chemicals.

OBJECTIVES: To identify the culprit allergen in this patient's spectacle frame.

MATERIALS AND METHODS: An extract from the temple arms was analysed by gas chromatography mass spectrometry (GC-MS), and a major low molecular weight compound was detected. This compound was isolated by semi-preparative high-performance liquid chromatography and identified by GC-MS and nuclear magnetic resonance spectroscopy. The purified compound was diluted in ethanol, and a dilution series was prepared for patch testing.

RESULTS: Triethylene glycol bis(2-ethylhexanoate) was identified as the major compound in the extract. Patch testing of the patient proved that triethylene glycol bis(2-ethylhexanoate) was the causative allergen in the spectacle frame. Ten consecutive eczema patients tested as controls were negative.

CONCLUSION: Triethylene glycol bis(2-ethylhexanoate) is a new, hitherto unreported contact allergen.

DOI 10.1111/cod.12152
Keywords Allergens; Dermatitis, Allergic Contact; Eyeglasses; Facial Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Patch Tests; Polyethylene Glycols; Scalp Dermatoses
ISSN 1600-0536
Citation Contact Derm. 2014;70(2):1126.

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