Ultrathin Tellurium Oxide/Ammonium Tungsten Bronze Nanoribbon for Multimodality Imaging and Second Near-Infrared Region Photothermal Therapy.

Author(s) Cheng, Y.; Yang, F.; Xiang, G.; Zhang, K.; Cao, Y.; Wang, D.; Dong, H.; Zhang, X.
Journal Nano Lett
Date Published 2019 02 13

Developing nanophotothermal agents (PTAs) with satisfied photothermal conversion efficiency (PTCE) in the second NIR window (1000-1350 nm, NIR II) holds great promise for enhanced photothermal therapy effect. Herein, we develop a NIR-II PTA with advanced PTCE, based on a new two-dimensional ultrathin tellurium oxide/ammonium tungsten bronze (TeO/(NH) WO) nanoribbons (TONW NRs). The doped ammonia ions-mediated-free-electrons injection into the lowest unoccupied molecular orbital band of WO combined with the electronic transitions between W ions and the lone pair of electrons in Te atoms achieve excellent NIR absorption of TONW NRs resulting from localized surface plasmon resonance. The polyethylene glycol functionalized TONW NRs (PEG-TONW NRs) exhibit good stability and biocompatibility, displaying a PTCE high to 43.6%, surpassing many previous nano-PTAs active in the NIR II region, leading to remarkable tumor ablation ability both in vitro and in vivo. Meanwhile, advanced X-ray computed tomography (CT) and photoacoustic (PA) imaging capability of PEG-TONW NRs were also realized. Given the admirable photothermal effect in NIR II region, good biocompatibility, and advanced CT/PA imaging diagnosis capability, the novel PEG-TONW NRs is promising in future personalized medicine applications.

DOI 10.1021/acs.nanolett.8b04618
ISSN 1530-6992
Citation Nano Lett. 2019;19(2):11791189.

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