Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams.
Title | Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams. |
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Authors | Zhou, B.; Li, L.; Zhu, X.Q.; Yan, J.Z.; Guo, Y.L.; Ye, L.W. |
Journal | Angew Chem Int Ed Engl |
DOI | 10.1002/anie.201700596 |
Abstract |
An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments. |