Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.

Title Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.
Authors S. Ray; U. Thormann; M. Eichelroth; M. Budak; C. Biehl; M. Rupp; U. Sommer; T.El Khassawna; F.I. Alagboso; M. Kampschulte; M. Rohnke; A. Henß; K. Peppler; V. Linke; P. Quadbeck; A. Voigt; F. Stenger; D. Karl; R. Schnettler; C. Heiss; K.S. Lips; V. Alt
Journal Biomaterials
DOI 10.1016/j.biomaterials.2017.11.049
Abstract

The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy and multi-deficient diet for 3 months. A 4 mm wedge shaped metaphyseal osteotomy was created, fixed with a mini-plate and subsequently filled with Fe, FeSr, FeBiP or left empty. After 6 weeks, ?Ct analysis revealed a statistically significant increased bone formation at the implant interface in FeSr compared to FeBiP (p = 0.035) and Fe (p = 0.002), respectively. Increased mineralized tissue was also seen within the pores in FeSr (p = 0.023) compared to Fe. Histomorphometry revealed significantly increased bone formation at the implant interface in FeSr (p < 0.001) and FeBiP (p = 0.006) compared to plain Fe with increased osteoblast and decreased osteoclast activity in combination with increased BMP2 and decreased RANKL/OPG in immunohistochemistry. ToF-SIMS analysis showed overlapping Ca signals with Fe for both FeSr and FeBiP thereby indicating tissue in-growth into the scaffolds. In conclusion, iron foam with strontium or bisphosphonate coating are of further interest in metaphyseal fracture defects in osteopenic bone.

Citation S. Ray; U. Thormann; M. Eichelroth; M. Budak; C. Biehl; M. Rupp; U. Sommer; T.El Khassawna; F.I. Alagboso; M. Kampschulte; M. Rohnke; A. Henß; K. Peppler; V. Linke; P. Quadbeck; A. Voigt; F. Stenger; D. Karl; R. Schnettler; C. Heiss; K.S. Lips; V. Alt.Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.. Biomaterials. 2018;157:116. doi:10.1016/j.biomaterials.2017.11.049

Related Elements

Iron

See more Iron products. Iron (atomic symbol: Fe, atomic number: 26) is a Block D, Group 8, Period 4 element with an atomic weight of 55.845. The number of electrons in each of Iron's shells is 2, 8, 14, 2 and its electron configuration is [Ar] 3d6 4s2. Iron Bohr ModelThe iron atom has a radius of 126 pm and a Van der Waals radius of 194 pm. Iron was discovered by humans before 5000 BC. In its elemental form, iron has a lustrous grayish metallic appearance. Iron is the fourth most common element in the Earth's crust and the most common element by mass forming the earth as a whole. Iron is rarely found as a free element, since it tends to oxidize easily; it is usually found in minerals such as magnetite, hematite, goethite, limonite, or siderite.Elemental Iron Though pure iron is typically soft, the addition of carbon creates the alloy known as steel, which is significantly stronger.

Strontium

See more Strontium products. Strontium (atomic symbol: Sr, atomic number: 38) is a Block S, Group 2, Period 5 element with an atomic weight of 87.62 . Strontium Bohr ModelThe number of electrons in each of Strontium's shells is [2, 8, 18, 8, 2] and its electron configuration is [Kr] 5s2. The strontium atom has a radius of 215 pm and a Van der Waals radius of 249 pm. Strontium was discovered by William Cruickshank in 1787 and first isolated by Humphry Davy in 1808. In its elemental form, strontium is a soft, silvery white metallic solid that quickly turns yellow when exposed to air. Elemental StrontiumCathode ray tubes in televisions are made of strontium, which are becoming increasingly displaced by other display technologies pyrotechnics and fireworks employ strontium salts to achieve a bright red color. Radioactive isotopes of strontium have been used in radioisotope thermoelectric generators (RTGs) and for certain cancer treatments. In nature, most strontium is found in celestite (as strontium sulfate) and strontianite (as strontium carbonate). Strontium was named after the Scottish town where it was discovered.

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