Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.

Title Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.
Authors R. Ayothiraman; S. Rangaswamy; P. Maity; E.M. Simmons; G.L. Beutner; J. Janey; D.S. Treitler; M.D. Eastgate; R. Vaidyanathan
Journal J Org Chem
DOI 10.1021/acs.joc.7b01101
Abstract

Zinc salts have been shown to promote the Buchwald-Hartwig coupling of azaindoles and azaindazoles with heteroaryl chlorides to provide the corresponding 1-aryl-1H-azaindoles and 1-aryl-1H-azaindazoles. The substrate scope and mechanistic aspects of this reaction were explored.

Citation R. Ayothiraman; S. Rangaswamy; P. Maity; E.M. Simmons; G.L. Beutner; J. Janey; D.S. Treitler; M.D. Eastgate; R. Vaidyanathan.Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.. J Org Chem. 2017. doi:10.1021/acs.joc.7b01101

Related Elements

Zinc

See more Zinc products. Zinc (atomic symbol: Zn, atomic number: 30) is a Block D, Group 12, Period 4 element with an atomic weight of 65.38. The number of electrons in each of zinc's shells is 2, 8, 18, 2, and its electron configuration is [Ar] 3d10 4s2. Zinc Bohr ModelThe zinc atom has a radius of 134 pm and a Van der Waals radius of 210 pm. Zinc was discovered by Indian metallurgists prior to 1000 BC and first recognized as a unique element by Rasaratna Samuccaya in 800. Zinc was first isolated by Andreas Marggraf in 1746. In its elemental form, zinc has a silver-gray appearance. It is brittle at ordinary temperatures but malleable at 100 °C to 150 °C.Elemental Zinc It is a fair conductor of electricity, and burns in air at high red producing white clouds of the oxide. Zinc is mined from sulfidic ore deposits. It is the 24th most abundant element in the earth's crust and the fourth most common metal in use (after iron, aluminum, and copper). The name zinc originates from the German word "zin," meaning tin.

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