About Stearates

Stearate Formula Diagram (C17h35coo-)

Stearates are salts or esters of stearic acid. Stearates have both hydrophilic and hydrophobic regions, allowing them to serve as surfactants, and are frequently produced during saponification processes, in which soaps are produced by treating fats with strong bases. Most commonly, the base used is sodium hydroxide or potassium hydroxide, which leads to the production of sodium or potassium stearates. Sodium stearate is found in many types of deodorants, rubbers, paints, and inks. Magnesium and calcium stearates are frequently used as an anti-adherent agent in pharmaceutical manufacturing. Zinc stearate is often referred to as a “zinc soap”, and has many important industrial uses.

Recent Research & Development for Stearates

Understanding the impact of magnesium stearate variability on tableting performance using a multivariate modeling approach., Wang, Ting, Ibrahim Ahmed, and Hoag Stephen W. , Pharm Dev Technol, 2020 Jan, Volume 25, Issue 1, p.76-88, (2020)

An Investigation of Magnesium Stearate Mixing Performance in a V-Blender Through Passive Vibration Measurements., Cameron, Austin, and Briens Lauren , AAPS PharmSciTech, 2019 May 24, Volume 20, Issue 5, p.199, (2019)

Development and Investigation of Lanthanum Sulfadiazine with Calcium Stearate and Epoxidised Soyabean Oil as Complex Thermal Stabilizers for Stabilizing Poly(vinyl chloride)., Ye, Qiufeng, Ma Xiaotao, Li Bobin, Jin Zhe, Xu Yingying, Fang Cheng, Zhou Xiaoya, Ge Yeqian, and Ye Feng , Polymers (Basel), 2019 Mar 21, Volume 11, Issue 3, (2019)

Ascorbyl stearate stimulates cell death by oxidative stress-mediated apoptosis and autophagy in HeLa cervical cancer cell line in vitro., Mane, Shirish Dinkar, and Kamatham Akhilender Naidu , 3 Biotech, 2019 Mar, Volume 9, Issue 3, p.115, (2019)

Design and Synthesis of a New Mannitol Stearate Ester-Based Aluminum Alkoxide as a Novel Tri-Functional Additive for Poly(Vinyl Chloride) and Its Synergistic Effect with Zinc Stearate., Han, Wenyuan, Zhang Manqi, Li Degang, Dong Tianbao, Ai Bing, Dou Jianping, and Sun Hongqi , Polymers (Basel), 2019 Jun 11, Volume 11, Issue 6, (2019)

Monitoring Magnesium Stearate Blending in a V-Blender Through Passive Vibration Measurements., Cameron, Austin, and Briens Lauren , AAPS PharmSciTech, 2019 Jul 26, Volume 20, Issue 7, p.269, (2019)

A peculiar case of sensitization to Candelilla Cera and sucrose (di)stearate in a toddler., Darrigade, Anne-Sophie, Dendooven Ella, Mangodt Evelyne, Vermander Evert, Hagendorens Margo, and Aerts Olivier , Contact Dermatitis, 2019 Aug 10, (2019)

Application of lanthanum stearate monolayers as a metal-affinity sorbent for the selective sorption of soman adducts to human serum albumin., Babakov, V N., Shreiner E V., Keltsieva O A., Dubrovskii Y A., Shilovskikh V V., Zorin I M., Sukhodolov N G., Zenkevich I G., Podolskaya E P., and Selyutin A A. , Talanta, 2019 Apr 01, Volume 195, p.728-731, (2019)

Elucidating the Variability of Magnesium Stearate and the Correlations With Its Spectroscopic Features., Wang, Ting, Potts Alan R., and Hoag Stephen W. , J Pharm Sci, 2019 04, Volume 108, Issue 4, p.1569-1580, (2019)

Cytotoxicity Enhancement of Paclitaxel by Loading on Stearate-g-dextran Micelles on Breast Cancer Cell Line MCF-7, Ghaffari, Fatemeh, Bahmanzadeh Maryam, Nili-Ahmadabadi Amir, and Firozian Farzin , Asian Pac J Cancer Prev, 2018 Sep 26, Volume 19, Issue 9, p.2651-2655, (2018)

Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole., Démuth, B, Galata D L., Balogh A, Szabó E, Nagy B, Farkas A, Hirsch E, Pataki H, Vigh T, Mensch J, et al. , Eur J Pharm Sci, 2018 Jun 15, Volume 121, p.301-308, (2018)

Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid nanoparticles in a direct compression process., Martínez-Acevedo, Lizbeth, Zambrano-Zaragoza María de la Luz, Vidal-Romero Gustavo, Mendoza-Elvira Susana, and Quintanar-Guerrero David , Int J Pharm, 2018 Jul 10, Volume 545, Issue 1-2, p.170-175, (2018)

The effect of mechanical dry coating with magnesium stearate on flowability and compactibility of plastically deforming microcrystalline cellulose powders., Koskela, Jaana, Morton David A. V., Stewart Peter J., Juppo Anne M., and Lakio Satu , Int J Pharm, 2018 Feb 15, Volume 537, Issue 1-2, p.64-72, (2018)

Liver-targeted delivery of liposome-encapsulated curcumol using galactosylated-stearate., Li, Wen-Jie, Lian You-Wen, Guan Quan-Sheng, Li Ning, Liang Wen-Jun, Liu Wen-Xin, Bin Huang Yong-, Cheng Yi, and Luo Hui , Exp Ther Med, 2018 Aug, Volume 16, Issue 2, p.925-930, (2018)