About Stearates

Stearate Formula Diagram (C17h35coo-)

Stearates are salts or esters of stearic acid. Stearates have both hydrophilic and hydrophobic regions, allowing them to serve as surfactants, and are frequently produced during saponification processes, in which soaps are produced by treating fats with strong bases. Most commonly, the base used is sodium hydroxide or potassium hydroxide, which leads to the production of sodium or potassium stearates. Sodium stearate is found in many types of deodorants, rubbers, paints, and inks. Magnesium and calcium stearates are frequently used as an anti-adherent agent in pharmaceutical manufacturing. Zinc stearate is often referred to as a “zinc soap”, and has many important industrial uses.

Recent Research & Development for Stearates

Gastroprotective properties of Lupeol-derived ester: Pre-clinical evidences of Lupeol-stearate as a potent antiulcer agent., Somensi, Lincon Bordignon, Costa Philipe, Boeing Thaise, Mariano Luísa Nathália, Longo Bruna, Magalhães Cássia Gonçalves, de Souza Priscila, de Andrade Sérgio Faloni, and da Silva Luisa Mota , Chem Biol Interact, 2020 Jan 29, p.108964, (2020)

Understanding the impact of magnesium stearate variability on tableting performance using a multivariate modeling approach., Wang, Ting, Ibrahim Ahmed, and Hoag Stephen W. , Pharm Dev Technol, 2020 Jan, Volume 25, Issue 1, p.76-88, (2020)

An Investigation of Magnesium Stearate Mixing Performance in a V-Blender Through Passive Vibration Measurements., Cameron, Austin, and Briens Lauren , AAPS PharmSciTech, 2019 May 24, Volume 20, Issue 5, p.199, (2019)

Development and Investigation of Lanthanum Sulfadiazine with Calcium Stearate and Epoxidised Soyabean Oil as Complex Thermal Stabilizers for Stabilizing Poly(vinyl chloride)., Ye, Qiufeng, Ma Xiaotao, Li Bobin, Jin Zhe, Xu Yingying, Fang Cheng, Zhou Xiaoya, Ge Yeqian, and Ye Feng , Polymers (Basel), 2019 Mar 21, Volume 11, Issue 3, (2019)

Ascorbyl stearate stimulates cell death by oxidative stress-mediated apoptosis and autophagy in HeLa cervical cancer cell line in vitro., Mane, Shirish Dinkar, and Kamatham Akhilender Naidu , 3 Biotech, 2019 Mar, Volume 9, Issue 3, p.115, (2019)

Design and Synthesis of a New Mannitol Stearate Ester-Based Aluminum Alkoxide as a Novel Tri-Functional Additive for Poly(Vinyl Chloride) and Its Synergistic Effect with Zinc Stearate., Han, Wenyuan, Zhang Manqi, Li Degang, Dong Tianbao, Ai Bing, Dou Jianping, and Sun Hongqi , Polymers (Basel), 2019 Jun 11, Volume 11, Issue 6, (2019)

Monitoring Magnesium Stearate Blending in a V-Blender Through Passive Vibration Measurements., Cameron, Austin, and Briens Lauren , AAPS PharmSciTech, 2019 Jul 26, Volume 20, Issue 7, p.269, (2019)

Multi-Fold Enhancement in Compressive Properties of Polystyrene Foam Using Pre-delaminated Stearate Functionalized Layer Double Hydroxides., Ogunsona, Emmanuel O., Dagnon Koffi L., and D'Souza Nandika Anne , Polymers (Basel), 2019 Dec 19, Volume 12, Issue 1, (2019)

Application of lanthanum stearate monolayers as a metal-affinity sorbent for the selective sorption of soman adducts to human serum albumin., Babakov, V N., Shreiner E V., Keltsieva O A., Dubrovskii Y A., Shilovskikh V V., Zorin I M., Sukhodolov N G., Zenkevich I G., Podolskaya E P., and Selyutin A A. , Talanta, 2019 Apr 01, Volume 195, p.728-731, (2019)

Stearate-Induced Apoptosis in Human Pancreatic β-Cells is Associated with Changes in Membrane Protein Expression and These Changes are Inhibited by Oleate., Němcová-Fürstová, Vlasta, Balušíková Kamila, Halada Petr, Pavlíková Nela, Šrámek Jan, and Kovář Jan , Proteomics Clin Appl, 2019 07, Volume 13, Issue 4, p.e1800104, (2019)

Elucidating the Variability of Magnesium Stearate and the Correlations With Its Spectroscopic Features., Wang, Ting, Potts Alan R., and Hoag Stephen W. , J Pharm Sci, 2019 04, Volume 108, Issue 4, p.1569-1580, (2019)

Cytotoxicity Enhancement of Paclitaxel by Loading on Stearate-g-dextran Micelles on Breast Cancer Cell Line MCF-7, Ghaffari, Fatemeh, Bahmanzadeh Maryam, Nili-Ahmadabadi Amir, and Firozian Farzin , Asian Pac J Cancer Prev, 2018 Sep 26, Volume 19, Issue 9, p.2651-2655, (2018)

Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole., Démuth, B, Galata D L., Balogh A, Szabó E, Nagy B, Farkas A, Hirsch E, Pataki H, Vigh T, Mensch J, et al. , Eur J Pharm Sci, 2018 Jun 15, Volume 121, p.301-308, (2018)

Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid nanoparticles in a direct compression process., Martínez-Acevedo, Lizbeth, Zambrano-Zaragoza María de la Luz, Vidal-Romero Gustavo, Mendoza-Elvira Susana, and Quintanar-Guerrero David , Int J Pharm, 2018 Jul 10, Volume 545, Issue 1-2, p.170-175, (2018)