Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic.

Title Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic.
Authors Y. Li; Y. Qi; H. Zhang; Z. Xia; T. Xie; W. Li; D. Zhong; H. Zhu; M. Zhou
Journal Biomaterials
DOI 10.1016/j.biomaterials.2019.119538
Abstract

Based on the ionizing radiation applied to the malignant tumor tissue, radiation therapy (RT) is the frequently-used non-surgical approach for cancer treatment. Hafnium Oxide (HfO) based nanoagent has been used in clinical trials for radiosensitized tumor therapy. However, the current reported clinically used HfO nanoparticles are relay on intratumoral injectable, and the unmodified HfO nanoparticles tend to be aggregated in serum and cannot be injected by intravenous route, which significantly limited the types of treatable cancer. To overcome the limitation, in this work, we developed a large-scalable, intravenously injectable, and clearable HfO nanoassemblies (NAs) to enhance the radiotherapeutic effects. The HfO NAs exhibited meaningfully promoted free-radical generation upon X-ray radiation for cancer cell killing due to the improved the sensitiveness of the breast cancer cells. The PEGylated HfO NAs demonstrated efficient tumor-homing ability via intravenous injection and manifested by HfO NAs enhanced CT imaging in a 4T1 breast tumor model. Utilizing the radiation sensitization function of HfO NAs, excellent tumor killing efficacy was achieved via both intratumoral and intravenously injection administration. Importantly, our HfO NAs could be degraded and excreted efficiently in a reasonable period in living body and avoid long-term toxicity. Taken together, our work provides a new technique by an injectable CT imaging-guided radio-sensitivitiable nanosystem for the further potential clinic translation.

Citation Y. Li; Y. Qi; H. Zhang; Z. Xia; T. Xie; W. Li; D. Zhong; H. Zhu; M. Zhou.Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic.. Biomaterials. 2020;226:119538. doi:10.1016/j.biomaterials.2019.119538

Related Elements

Hafnium

See more Hafnium products. Hafnium (atomic symbol: Hf, atomic number: 72) is a Block D, Group 4, Period 6 element with an atomic weight of 178.49. Hafnium Bohr ModelThe number of electrons in each of Hafnium's shells is 2, 8, 18, 32, 10, 2 and its electron configuration is [Xe] 4f14 5d2 6s2. The hafnium atom has a radius of 159 pm and a Van der Waals radius of 212 pm. Hafnium was predicted by Dmitri Mendeleev in 1869 but it was not until 1922 that it was first isolated Dirk Coster and George de Hevesy. In its elemental form, hafnium has a lustrous silvery-gray appearance. Elemental HafniumHafnium does not exist as a free element in nature. It is found in zirconium compounds such as zircon. Hafnium is often a component of superalloys and circuits used in semiconductor device fabrication. Its name is derived from the Latin word Hafnia, meaning Copenhagen, where it was discovered.

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