Gastric lanthanosis (lanthanum deposition) in dialysis patients treated with lanthanum carbonate.

Title Gastric lanthanosis (lanthanum deposition) in dialysis patients treated with lanthanum carbonate.
Authors Y. Shitomi; H. Nishida; T. Kusaba; T. Daa; S. Yano; M. Arakane; Y. Kondo; T. Nagai; T. Abe; A. Gamachi; K. Murakami; T. Etoh; N. Shiraishi; M. Inomata; S. Yokoyama
Journal Pathol Int
DOI 10.1111/pin.12558
Abstract

Lanthanum carbonate (LaC) is used to prevent hyperphosphatemia in dialysis patients. It is commonly believed that there is little LaC absorption from the intestines. However, La deposition in the gastric mucosa, which we coined "gastric lanthanosis", was recently reported. We describe here the clinicopathological features of and a possible mechanism for gastric lanthanosis. This study included 23 patients with definite gastric lanthanosis. We extracted characteristic clinicopathological features of gastric lanthanosis by computed tomography (CT) imaging and endoscopic, histologic, electron-microscopic, and element analysis examinations. The Helicobacter pylori infection rate in the lanthanosis group was much lower than that among the general population. The clinicopathological features characteristic of gastric lanthanosis were mucosal high-density linear appearance by CT, reflective bright-white spots (BWS) by gastroscopy, eosinophilic histiocytes occasionally phagocytizing foreign materials by histology, and numerous electron-dense particles in the histiocytes. The particles had burr-like skeletons resembling La crystals. Gastric lanthanosis is an under-reported, but not a rare lesion. It is characterized by endoscopic BWS and histologic eosinophilic histiocytes in dialysis patients treated with LaC. The proposed mechanism for gastric lanthanosis is that LaC is dissolved by gastric juice, crystallized within the mucosa and is phagocytized by histiocytes.

Citation Y. Shitomi; H. Nishida; T. Kusaba; T. Daa; S. Yano; M. Arakane; Y. Kondo; T. Nagai; T. Abe; A. Gamachi; K. Murakami; T. Etoh; N. Shiraishi; M. Inomata; S. Yokoyama.Gastric lanthanosis (lanthanum deposition) in dialysis patients treated with lanthanum carbonate.. Pathol Int. 2017. doi:10.1111/pin.12558

Related Elements

Lanthanum

See more Lanthanum products. Lanthanum (atomic symbol: La, atomic number: 57) is a Block F, Group 3, Period 6 element with an atomic weight of 138.90547. Lanthanum Bohr ModelThe number of electrons in each of lanthanum's shells is [2, 8, 18, 18, 9, 2] and its electron configuration is [Xe] 5d1 6s2. The lanthanum atom has a radius of 187 pm and a Van der Waals radius of 240 pm. Lanthanum was first discovered by Carl Mosander in 1838. In its elemental form, lanthanum has a silvery white appearance.Elemental Lanthanum It is a soft, malleable, and ductile metal that oxidizes easily in air. Lanthanum is the first element in the rare earth or lanthanide series. It is the model for all the other trivalent rare earths and it is the second most abundant of the rare earths after cerium. Lanthanum is found in minerals such as monazite and bastnasite. The name lanthanum originates from the Greek word Lanthaneia, which means 'to lie hidden'.

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