Lanthanum deposition from oral lanthanum carbonate in the upper gastrointestinal tract.

Title Lanthanum deposition from oral lanthanum carbonate in the upper gastrointestinal tract.
Authors R.S. Hoda; S. Sanyal; J.L. Abraham; J.M. Everett; G.L. Hundemer; E. Yee; G.Y. Lauwers; N. Tolkoff-Rubin; J. Misdraji
Journal Histopathology
DOI 10.1111/his.13178
Abstract

AIMS: Lanthanum carbonate is used as an alternative to calcium-based phosphate binders to manage hyperphosphataemia in patients with renal failure. The deposition of lanthanum within gastroduodenal mucosa of patients treated with the medication has been described, but given the relative novelty of this entity, the histiocytic deposits in the gastroduodenal mucosa can be confused with a variety of other processes, including infections and other drug-induced forms of injury.

METHODS AND RESULTS: We describe five cases of lanthanum phosphate deposition in upper gastrointestinal (GI) tract biopsies. Three cases were confirmed with scanning electron microscopy and energy dispersive X-ray analysis, including one unique patient, status post-renal transplant for polycystic kidney disease, who had last taken lanthanum 7 years prior to biopsy.

CONCLUSION: Lanthanum deposition in the upper GI tract is a mimic of other drug-related forms of GI injury, including iron pill-related gastropathy. The key to making this diagnosis is a thorough drug history and awareness of the histological features.

Citation R.S. Hoda; S. Sanyal; J.L. Abraham; J.M. Everett; G.L. Hundemer; E. Yee; G.Y. Lauwers; N. Tolkoff-Rubin; J. Misdraji.Lanthanum deposition from oral lanthanum carbonate in the upper gastrointestinal tract.. Histopathology. 2017;70(7):10721078. doi:10.1111/his.13178

Related Elements

Lanthanum

See more Lanthanum products. Lanthanum (atomic symbol: La, atomic number: 57) is a Block F, Group 3, Period 6 element with an atomic weight of 138.90547. Lanthanum Bohr ModelThe number of electrons in each of lanthanum's shells is [2, 8, 18, 18, 9, 2] and its electron configuration is [Xe] 5d1 6s2. The lanthanum atom has a radius of 187 pm and a Van der Waals radius of 240 pm. Lanthanum was first discovered by Carl Mosander in 1838. In its elemental form, lanthanum has a silvery white appearance.Elemental Lanthanum It is a soft, malleable, and ductile metal that oxidizes easily in air. Lanthanum is the first element in the rare earth or lanthanide series. It is the model for all the other trivalent rare earths and it is the second most abundant of the rare earths after cerium. Lanthanum is found in minerals such as monazite and bastnasite. The name lanthanum originates from the Greek word Lanthaneia, which means 'to lie hidden'.

Related Forms & Applications