Multiporous molybdenum carbide nanosphere as a new charming electrode material for highly sensitive simultaneous detection of guanine and adenine.

By introduction of Mo metal species (molybdenum-based polyoxometalates) into the Cu-MOF as co-precursor, molybdenum carbide nanosphere (MoC@C) was prepared via a simple calcining routine and a further etching the metallic Cu process. The obtained MoC@C showed a unique structure where well-dispersed MoC nanoparticles (NPs) were encapsulated in porous carbon matrix. As-fabricated novel 3D porous architecture MoC@C nanosphere exhibited a potent and persistent electro-oxidation behavior followed by well-separated oxidation peaks (peak to peak voltage is about 350?mV) toward adenine (A) and guanine (G) by differential pulse voltammetry (DPV). This excellent electrochemical performance can be attributed to the unique structure and composition of 3D MoC@C. Furthermore, 3D MoC@C also revealed high selectivity and sensitivity, good reproducibility, excellent stability and anti-interference ability. The calibration curves for quantitive analysis of G and A were obtained: 0.03-122?µM, and 0.02-122?µM, respectively, the detection limits were 0.0085?µM, 0.008?µM, respectively. The proposed procedure was successfully applied to detect G and A in human urine and serum samples with satisfactory recovery, which manifests its viability application for practical analysis.