Potassium bromate-induced kidney damage in rats and the effect of gum acacia thereon.

Title Potassium bromate-induced kidney damage in rats and the effect of gum acacia thereon.
Authors B.H. Ali; M.Al Za'abi; T. Karaca; Y.Al Suleimani; K.A.Al Balushi; P. Manoj; M. Ashique; A. Nemmar
Journal Am J Transl Res
DOI
Abstract

Potassium bromate (KBrO) is used in many countries in cosmetic and food industries. In this work, we investigated in male Sprague-Dawley rats, the effect of four graded oral doses of KBrO (5, 15, 45 and 135 mg/kg/day for 28 days) on renal function tests, inflammation, oxidative damage, and apoptosis, as well as on histopathology, using several traditional and novel renal injury biomarkers in plasma, urine and renal tissues. We also tested the possible ameliorative action of the renoprotective prebiotic agent gum acacia (GA) on the actions of KBrO when given concomitantly with it in the drinking water at a concentration of 15%. Taken together, the results indicated that treatment with KBrO at the 45 and 135 mg/kg doses caused a significant dose-dependent nephrotoxicity, as evident by the measured renal structural and functional indices and biomarkers of toxicity. GA co-treatment significantly abated most of the indices and biomarkers of the renal toxicity caused by KBrO, suggesting a beneficial effect and its possible inclusion in edible products where KBrO is still used.

Citation B.H. Ali; M.Al Za'abi; T. Karaca; Y.Al Suleimani; K.A.Al Balushi; P. Manoj; M. Ashique; A. Nemmar.Potassium bromate-induced kidney damage in rats and the effect of gum acacia thereon.. Am J Transl Res. 2018;10(1):126137. doi:

Related Elements

Bromine

See more Bromine products. Bromine (atomic symbol: Br, atomic number: 35) is a Block P, Group 17, Period 4 element. Its electron configuration is [Ar]4s23d104p5. The bromine atom has a radius of 102 pm and its Van der Waals radius is 183 pm. In its elemental form, bromine Bromine Bohr Model has a red-brown appearance. Bromine does not occur by itself in nature; it is found as colorless soluble crystalline mineral halide salts. Bromine was discovered and first isolated by Antoine Jérôme Balard and Leopold Gmelin in 1825-1826.

Potassium

Elemental PotassiumSee more Potassium products. Potassium (atomic symbol: K, atomic number: 19) is a Block S, Group 1, Period 4 element with an atomic weight of 39.0983. The number of electrons in each of Potassium's shells is [2, 8, 8, 1] and its electron configuration is [Ar] 4s1. The potassium atom has a radius of 227.2 pm and a Van der Waals radius of 275 pm. Potassium was discovered and first isolated by Sir Humphrey Davy in 1807. Potassium is the seventh most abundant element on earth. It is one of the most reactive and electropositive of all metals and rapidly oxidizes. As with other alkali metals, potassium decomposes in water with the evolution of hydrogen because of its reacts violently with water, it only occurs in nature in ionic salts.Potassium Bohr Model In its elemental form, potassium has a silvery gray metallic appearance, but its compounds (such as potassium hydroxide) are more frequently used in industrial and chemical applications. The origin of the element's name comes from the English word 'potash,' meaning pot ashes, and the Arabic word qali, which means alkali. The symbol K originates from the Latin word kalium.

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