Prostate Cancer Cell-Specific Cytotoxicity of Sub-Micron Potassium Niobate Powder.

Title Prostate Cancer Cell-Specific Cytotoxicity of Sub-Micron Potassium Niobate Powder.
Authors J.G. Fisher; U.Trong Thuan; M.Umer Farooq; G. Chandrasekaran; Y.Do Jung; E.Chang Hwang; J.J. Lee; V.K. Lakshmanan
Journal J Nanosci Nanotechnol
DOI 10.1166/jnn.2018.14666
Abstract

Oxide nanoparticles have numerous potential applications in medicine such as carriers for therapeutic drugs, contrast agents for bio-imaging and targeting agents for tumors. Oxide nanoparticles may also have an inherent cytotoxicity towards cancer cells, as recently found for cerium oxide. KNbO3 nanoparticles have a combination of low toxicity and nonlinear optical properties which make them attractive for use as a bio-imaging material. However, little is known yet about the cytotoxicity of KNbO3 particles towards cancerous cells. In the present work, the cytotoxicity of KNbO3 particles to normal and prostate cancer cell lines is studied. The mixed oxide method is used to prepare KNbO3 powder. Using dynamic light scattering the mean particle diameter of the KNbO3 powder is found to be ?500 nm. X-ray diffraction, Fourier transform infra-red spectroscopy and Raman scattering spectroscopy are used to examine the structure of the KNbO3 powder. Powder morphology is examined using scanning electron microscopy. MTT assays of EA.hy926, PC-3 and DU-145 cell lines are carried out to study cell-specific cytotoxicity. KNbO3 sub-micron particles are found to have low toxicity to PC-3 cells, moderate toxicity to EA.hy926 cells and high toxicity to DU-145 cells. A new avenue towards the treatment of prostate cancer may be opened by the cell-specific cytotoxicity of KNbO3.

Citation J.G. Fisher; U.Trong Thuan; M.Umer Farooq; G. Chandrasekaran; Y.Do Jung; E.Chang Hwang; J.J. Lee; V.K. Lakshmanan.Prostate Cancer Cell-Specific Cytotoxicity of Sub-Micron Potassium Niobate Powder.. J Nanosci Nanotechnol. 2018;18(5):31413147. doi:10.1166/jnn.2018.14666

Related Elements

Niobium

See more Niobium products. Niobium (atomic symbol: Nb, atomic number: 41) is a Block D, Group 5, Period 5 element with an atomic weight of 92.90638. Niobium Bohr ModelThe number of electrons in each of niobium's shells is 2, 8, 18, 12, 1 and its electron configuration is [Kr] 4d4 5s1. The niobium atom has a radius of 146 pm and a Van der Waals radius of 207 pm. Niobium was discovered by Charles Hatchett in 1801 and first isolated by Christian Wilhelm Blomstrand in 1864. In its elemental form, niobium has a gray metallic appearance. Niobium has the largest magnetic penetration depth of any element and is one of three elemental type-II superconductors (Elemental Niobiumalong with vanadium and technetium). Niobium is found in the minerals pyrochlore, its main commercial source, and columbite. The word Niobium originates from Niobe, daughter of mythical Greek king Tantalus.

Potassium

Elemental PotassiumSee more Potassium products. Potassium (atomic symbol: K, atomic number: 19) is a Block S, Group 1, Period 4 element with an atomic weight of 39.0983. The number of electrons in each of Potassium's shells is [2, 8, 8, 1] and its electron configuration is [Ar] 4s1. The potassium atom has a radius of 227.2 pm and a Van der Waals radius of 275 pm. Potassium was discovered and first isolated by Sir Humphrey Davy in 1807. Potassium is the seventh most abundant element on earth. It is one of the most reactive and electropositive of all metals and rapidly oxidizes. As with other alkali metals, potassium decomposes in water with the evolution of hydrogen because of its reacts violently with water, it only occurs in nature in ionic salts.Potassium Bohr Model In its elemental form, potassium has a silvery gray metallic appearance, but its compounds (such as potassium hydroxide) are more frequently used in industrial and chemical applications. The origin of the element's name comes from the English word 'potash,' meaning pot ashes, and the Arabic word qali, which means alkali. The symbol K originates from the Latin word kalium.

Related Forms & Applications