Proteomic identification of sperm from mice exposed to sodium fluoride.

Title Proteomic identification of sperm from mice exposed to sodium fluoride.
Authors Z. Sun; R. Wei; G. Luo; R. Niu; J. Wang
Journal Chemosphere
DOI 10.1016/j.chemosphere.2018.05.153

Fluoride is a widespread environmental pollutant which can induce low sperm quality and fertilizing ability. However, effect of fluoride on proteomic changes of sperm is unknown. In this study, two-dimensional electrophoresis (2DE) and mass spectrometry (MS) were used to investigate the differently expressed proteins of sperm from mice exposed to fluoride. 180 male mice were randomly divided into three groups, and were administrated with the distilled water containing 0, 25, and 100?mg?L NaF, respectively. After 45, 90 and 180 day's exposure, mice were sacrificed and sperm from the cauda epididymis and vas deferens were collected for 2DE. 16 differently expressed spots were picked up to identify using MS, 15 of which were successfully identified. Many of them are associated with the sperm function such as sperm motility, maturation, capacitation and acrosome reaction, lipid peroxidation, detoxification, inflammation, and stability of membrane structure. These results could contribute to the explanation and further research of mechanisms underlying sperm damage induced by fluoride.

Citation Z. Sun; R. Wei; G. Luo; R. Niu; J. Wang.Proteomic identification of sperm from mice exposed to sodium fluoride.. Chemosphere. 2018;207:676681. doi:10.1016/j.chemosphere.2018.05.153

Related Elements


Sodium Bohr ModelSee more Sodium products. Sodium (atomic symbol: Na, atomic number: 11) is a Block D, Group 5, Period 4 element with an atomic weight of 22.989769. The number of electrons in each of Sodium's shells is [2, 8, 1] and its electron configuration is [Ne] 3s1. The sodium atom has a radius of 185.8 pm and a Van der Waals radius of 227 pm. Sodium was discovered and first isolated by Sir Humphrey Davy in 1807. In its elemental form, sodium has a silvery-white metallic appearance. It is the sixth most abundant element, making up 2.6 % of the earth's crust. Sodium does not occur in nature as a free element and must be extracted from its compounds (e.g., feldspars, sodalite, and rock salt). The name Sodium is thought to come from the Arabic word suda, meaning "headache" (due to sodium carbonate's headache-alleviating properties), and its elemental symbol Na comes from natrium, its Latin name.


Fluorine is a Block P, Group 17, Period 2 element. Its electron configuration is [He]2s22p5. The fluorine atom has a covalent radius of 64 pm and its Van der Waals radius is 135 pm. In its elemental form, CAS 7782-41-4, fluorine gas has a pale yellow appearance. Fluorine was discovered by André-Marie Ampère in 1810. It was first isolated by Henri Moissan in 1886.

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