Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides.

Title Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides.
Authors Li, P.G.; Zhu, H.; Fan, M.; Yan, C.; Shi, K.; Chi, X.W.; Zou, L.H.
Journal Org Biomol Chem
DOI 10.1039/c9ob00822e
Abstract

Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides. This process involves N-O/C-O bond cleavages and C-N bond formation. Furthermore, the decarboxylation of α-keto acids can be successfully suppressed under redox-neutral conditions.

Citation Li, P.G.; Zhu, H.; Fan, M.; Yan, C.; Shi, K.; Chi, X.W.; Zou, L.H..Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides..

Related Elements

Copper

See more Copper products. Copper Bohr Model Copper (atomic symbol: Cu, atomic number: 29) is a Block D, Group 11, Period 4 element with an atomic weight of 63.546. The number of electrons in each of copper's shells is 2, 8, 18, 1 and its electron configuration is [Ar]3d10 4s1. The copper atom has a radius of 128 pm and a Van der Waals radius of 186 pm. Copper was first discovered by Early Man prior to 9000 BC. In its elemental form, copper has a reddish-orange metallic and lustrous appearance. Of all pure metals, only silver Elemental Copperhas a higher electrical conductivity. The origin of the word copper comes from the Latin word 'cuprium' which translates as "metal of Cyprus," as the Mediterranean island of Cyprus was known as an ancient source of mined copper..