Structure and dysprosium dopant engineering of gadolinium oxide nanoparticles for enhanced dual-modal magnetic resonance and fluorescence imaging.

Title Structure and dysprosium dopant engineering of gadolinium oxide nanoparticles for enhanced dual-modal magnetic resonance and fluorescence imaging.
Authors J. Yin; C. Li; D. Chen; J. Yang; H. Liu; W. Hu; Y. Shao
Journal Phys Chem Chem Phys
DOI 10.1039/c6cp06712c
Abstract

We report a class of multi-functional core-shell nanoarchitectures, consisting of silica nanospheres as the core and Gd2O3:Dy(3+) nanocrystals as the ultra-thin shell, that enable unique multi-color living cell imaging and remarkable in vivo magnetic resonance imaging. These types of targeted cell imaging nanoarchitectures can be used as a variety of fluorescence nanoprobes due to the multi-color emissions of the Gd2O3:Dy(3+) nanophosphor. We also proposed a strategy of modulating core-shell structure design to achieve an enhanced magnetic resonance contrast ability of Gd2O3 nanoagents, and the classical Solomon-Bloembergen-Morgan theory was applied to explicate the mechanism underlying the enhancement. The as-synthesized ligand-free nanomaterial possesses a suitable particle size for cellular uptake as well as avoiding penetrating the blood-brain barrier with good water-solubility, stability, dispersibility and uniformity. The extremely low cytotoxicity and favorable biocompatibility obtained from in vitro and in vivo bioassays of the as-designed nanoparticles indicate their excellent potential as a candidate for functioning as a targeted nanoprobe.

Citation J. Yin; C. Li; D. Chen; J. Yang; H. Liu; W. Hu; Y. Shao.Structure and dysprosium dopant engineering of gadolinium oxide nanoparticles for enhanced dual-modal magnetic resonance and fluorescence imaging.. Phys Chem Chem Phys. 2017;19(7):53665376. doi:10.1039/c6cp06712c

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Dysprosium

See more Dysprosium products. Dysprosium (atomic symbol: Dy, atomic number: 66) is a Block F, Group 3, Period 6 element with an atomic radius of 162.5. Dysprosium Bohr ModelThe number of electrons in each of dysprosium's shells is [2, 8, 18, 28, 8, 2] and its electron configuration is [Xe]4f10 6s2. The dysprosium atom has an atomic radius of 178 pm and a Van der Waals radius of 229 pm. Dysprosium was first discovered by Paul Emile Lecoq de Boisbaudran in 1886. In its elemental form, dysprosium has a silvery-white appearance. Elemental Dysprosium PictureIt is a member of the lanthanide or rare earth series of elements and, along with holmium, has the highest magnetic strength of all other elements on the periodic table, especially at low temperatures. Dysprosium is found in various minerals including bastnäsite, blomstrandine, euxenite, fergusonite, gadolinite, monazite, polycrase and xenotime. It is not found in nature as a free element. The element name originates from the Greek word dysprositos, meaning hard to get at.

Gadolinium

See more Gadolinium products. Gadolinium (atomic symbol: Gd, atomic number: 64) is a Block F, Group 3, Period 6 element with an atomic radius of 157.25. Gadolinium Bohr ModelThe number of electrons in each of Gadolinium's shells is [2, 8, 18, 25, 9, 2] and its electron configuration is [Xe] 4f7 5d1 6s2. The gadolinium atom has a radius of 180 pm and a Van der Waals radius of 237 pm. Gadolinium was discovered by Jean Charles Galissard de Marignac in 1880 and first isolated by Lecoq de Boisbaudran in 1886. In its elemental form, gadolinium has a silvery-white appearance. Gadolinium is a rare earth or lanthanide element that possesses unique properties advantageous to specialized applications such as semiconductor fabrication and nuclear reactor shielding. Elemental Gadolinium PictureIt is utilized for both its high magnetic moment (7.94μ B) and in phosphors and scintillator crystals. When complexed with EDTA ligands, it is used as an injectable contrast agent for MRIs. The element is named after the Finnish chemist and geologist Johan Gadolin.

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