Europium-Doped Cerium Oxide Nanoparticles Limit Reactive Oxygen Species Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury.

Title Europium-Doped Cerium Oxide Nanoparticles Limit Reactive Oxygen Species Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury.
Authors E.O. Gubernatorova; X. Liu; A. Othman; W.T. Muraoka; E.P. Koroleva; S. Andreescu; A.V. Tumanov
Journal Adv Healthc Mater
DOI 10.1002/adhm.201700176
Abstract

Accumulating evidence suggests that ischemia-reperfusion-induced injury is associated with the formation of reactive oxygen species (ROS). This study demonstrates the therapeutic effectiveness of novel europium-doped cerium oxide nanoparticles (Eu-doped Ceria NPs) as ROS scavengers in a mouse model of intestinal ischemia-reperfusion-induced injury. An increased production of superoxide radicals is detected in the intestine throughout the ischemia stage and again after initiating reperfusion. These changes in superoxide radical formation are associated with the induction of inflammatory cytokines in the intestine. This study further shows that Eu-Ceria NPs exhibit superoxide scavenging activity in vitro. Importantly, administration of Eu-Ceria NPs into the intestinal lumen during the onset of ischemia effectively blocks superoxide accumulation, reduces the expression of IL-1b, and ameliorates the intestinal pathology. These results suggest that early increased production of ROS during the ischemia-reperfusion promotes intestinal pathology and that mucosal delivery of Eu-Ceria NPs may be a potential therapeutic approach to block ROS accumulation and ameliorate the severity of intestinal disease.

Citation E.O. Gubernatorova; X. Liu; A. Othman; W.T. Muraoka; E.P. Koroleva; S. Andreescu; A.V. Tumanov.Europium-Doped Cerium Oxide Nanoparticles Limit Reactive Oxygen Species Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury.. Adv Healthc Mater. 2017. doi:10.1002/adhm.201700176

Related Elements

Cerium

See more Cerium products. Cerium (atomic symbol: Ce, atomic number: 58) is a Block F, Group 3, Period 6 element with an atomic weight of 140.116. The number of electrons in each of cerium's shells is 2, 8, 18, 19, 9, 2 and its electron configuration is [Xe]4f2 6s2. Cerium Bohr ModelThe cerium atom has a radius of 182.5 pm and a Van der Waals radius of 235 pm. In its elemental form, cerium has a silvery white appearance. Cerium is the most abundant of the rare earth metals. It is characterized chemically by having two valence states, the +3 cerous and +4 ceric states. The ceric state is the only non-trivalent rare earth ion stable in aqueous solutions. Elemental CeriumIt is therefore strongly acidic and oxidizing, in addition to being moderately toxic.The cerous state closely resembles the other trivalent rare earths. Cerium is found in the minerals allanite, bastnasite, hydroxylbastnasite, monazite, rhabdophane, synchysite and zircon. Cerium was discovered by Martin Heinrich Klaproth, Jöns Jakob Berzelius, and Wilhelm Hisinger in 1803 and first isolated by Carl Gustaf Mosander in 1839. The element was named after the asteroid Ceres, which itself was named after the Roman god of agriculture.

Europium

See more Europium products. Europium (atomic symbol: Eu, atomic number: 63) is a Block F, Group 3, Period 6 element with an atomic radius of 151.964. Europium Bohr ModelThe number of electrons in each of Europium's shells is 2, 8, 18, 25, 8, 2 and its electron configuration is [Xe]4f7 6s2. The europium atom has an atomic radius of 180 pm and a Van der Waals radius of 233 pm. Europium was discovered by Eugène-Anatole Demarçay in 1896, however, he did not isolate it until 1901. Europium was named after the continent of Europe.Elemental Europium Picture Europium is a member of the lanthanide or rare earth series of metals. In its elemental form, it has a silvery-white appearance but it is rarely found without oxide discoloration. Europium is found in many minerals including bastnasite, monazite, xenotime and loparite. It is not found in nature as a free element.

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